New study mobilizes T cells to become therapeutic + State of the Science in Regenerative Medicine Workshop Coming Up
New study describes mobilization of adult T cells to become therapeutic
We wanted to highlight an interesting new paper that came out this week with potentially significant applications for adoptive T cell therapy. In this type of therapy, tumor-specific T cells are isolated and expanded ex vivo prior to being administered. T cells in adult bodies are typically maintained by the differentiation of a small population of adult stem cells.
A new study study, published in the Journal of Clinical Investigation, described the identification of genes involved in the mobilization of a quiescent subset of tissue-resident memory (Trm) cells. The genes are ABC transporters and the NR4A family of transcription factors, and they influence the function and differentiation of Trm cells.
in doing so, the authors effectively were able to “boost” and create Trm cells from otherwise quiescent T cells, which would have a significant impact in adoptive T cell therapy, which relies on sufficient numbers of T cells for efficacy.
The study came out of the lab of Dr. Madhav V. Dhodapkar at the Department of Medicine at Yale University and can be read here in full.
Akron to attend Cell & Gene Meeting on the Mesa Partnering Forum
As previous years, Akron will this year attend the upcoming Cell & Gene Meeting on the Mesa, and will participate in the preceding Partnering Forum. The Partnering Forum takes place October 5 – 6, 2016 and brings together over 500 participants from every facet of the academic, research, cell and gene therapy and pharmaceutical as well as business fields. If you want to meet us please check partnering session opportunities at the Cell & Gene Meeting on the Mesa website or contact us directly.
State of the Science in the Field of Regenerative Medicine: Challenges of and Opportunities for Cellular Therapies – A Workshop
We are also excited to share some information about a workshop by the Forum on Regenerative Medicine at the National Academies of Science, Engineering and Medicine, set to take place on October 13.
The purpose of the workshop is to highlight, and discuss, challenges associated with developing cell-based therapies for regenerative medicine. The planning committee has developed a great agenda for the day (link below) and the public registration is now open. We encourage you all to share the information with colleagues who may be interested in attending. The workshop takes place on October 13th at the National Academy of Sciences Building (125) • 2101 Constitution Avenue, NW, Washington, DC with an 8:30 AM start time.