Fibronectin: Critical role in cell behavior highlighted in new review

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Fibronectin is one of the most important proteins of the extracellular matrix, responsible for such critical functions as cell differentiation, morphogenesis, migration, and therapeutic roles that include wound healing. Alongside proteins which include laminin, collagen and vitronectin, fibronectin is a critical component of the cell survival cascade.

We have written extensively about fibronectin in the past, both within the context of its function as well as about improvements in its production methods, which Akron is a pioneer of.

The critical role of fibronectin was once again detailed on a comprehensive recent review published by Dr. Maria Vega and Dr. Jean Schwarzbauer at Princeton University.

Titled “Collaboration of fibronectin matrix with other extracellular signals in morphogenesis and differentiation,” the review was published in the October 2016 issue of Current Opinion in Cell Biology, online from last month.

You can access the manuscript here.

The review is a comprehensive overview of the role of fibronectin in cell differentiation, morphogenesis and tissue repair , and covers the ECM protein’s function which includes its interaction with its receptor α5β1 integrin, and how this interactions affects cell behavior.

Integrin α5β1, also called fibronectin receptor, plays important roles in solid tumors and physiological angiogenesis, functions that have been studied for over two decades, and that are closely intertwined with those of fibronectin. Owing to its high affinity for fibronectin, integrin α5β1 is considered one of the most efficient mediators of fibronectin activity compared to other integrins.

Clinical uses of fibronectin in regenerative medicine pose additional requirements on the protein which are closely related to its production method, purity and recovery and their effects on the protein’s in vitro and in vivo activity. At Akron, our expertise on fibronectin spans all of these important considerations, and is reflected in our ability to provide fibronectin at multiple quality grades: research, GMP-grade as well as virally inactivated. Contact us to discuss your application and how we can help you implement fibtronectin in your studies.

 

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