Adipose-Derived Stem Cells in the Clinic: A Paper Roundup

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In this roundup of scientific papers of note we focus on the recent influx of papers focusing on adipose-derived stem cells and their growing use in therapy: here are some of recent studies of note that have appeared in the last few weeks, summarized for easy reading.

Implications for human adipose-derived stem cells in plastic surgery. 
In an interesting review on the applications of adipose tissue-derived stem cells (ADSCs) in plastic surgery, Dereck Banyard et al. discuss the ways ADSCs are currently used in the clinical setting and present both the advantages and limitations currently faced on the road to the clinic. Clinical therapies they discuss include soft tissue repair, bone and cartilage repair, wound healing, as well as peripheral nerve regeneration. Link here.

Enrichment of adipose-derived stem cells: comparison of lipotransfer techniques.
Focusing on patients undergoing breast reconstruction by lipotransfer, Rossana Domenis and colleagues analyzed four commercial tehniques for breast reconstruction: Cytori Celution System, Lipokit Medikhan Syste, Fastem Corios as well as a more traditional enzyme-based approach: a modified Coleman’s procedure using collagenase. They published their data last week in Stem Cell Research. After studying stem cell yield, proliferation and differentiation capacity obtained with all four methods, the authors found that the enzymatic approach is clinically superior to the alternative commercial systems by significantly reducing graft resorption measured after one year. Read the full study here.

Stromal cells and stem cells in clinical bone regeneration.
Warren Grayson and colleagues at Johns Hopkins University discuss, in a review just published in Nature Reviews Endocrinology, the use of bone-marrow-derived mesenchymal or adipose-tissue-derived stromal cells in the clinical setting. By compiling and analyzing data extracted from a number of relevant clinical trials employing mesenchymal and stromal cells, the authors draw conclusions as to the present difficulties styming the mainstream use of these cells in the clinic, with a particular emphasis on skeletal repair, and offer insights into the future. Link to study here.

Adipose-derived stem cells improve wound healing following burn.
Small steps toward demonstrating the effectiveness in using ADSCs in reconstructive surgery were made by Shawn Loder and colleagues, who just published a paper demonstrating a study, done in mice, on using ADSC to kickstart the wound healing process. By treating, via subcutaneous injection, mouse models of burn injury with ADSCs from inguinal fat pads, the authors showed that improved healing over controls defined by decreased wound depth, area, and apoptotic activity, was obtained in models treated with ADSC. This did not translate to improved vascularization further down the line, but is nonetheless a promising model for early-stage wound repair. Link here.

ADSCs inhibit melanoma growth in vitro and in vivo.
Anticancer Research just published an interesting study, by Hwa-Yong Youn’s group at Seoul National University, that evaluated the anti-tumor effect of ADSCs in vitro and in vivo. The authors found that, through an alteration in cell-cycle distribution, ADSCs inhibit melanoma growth and the further spreading of the tumor. A number of in vitro assays as well as in vivo models were used to test this hypothesis, which has significant implications for the potential use of ADSCs in the melanoma treatment. Link to paper here.





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