The extracellular matrix is involved in critical signaling pathways that regulate cell phenotype and function. In order to carry out these important functions, cells need to interact and adhere specifically to both cellular and extracellular components of their environment. Many of these functions are regulated by a number of cellular growth factors. Last week, we highlighted the role of the fibroblast growth factor (FGF) family as an important modulator of cell growth and differentiation, among many other functions including weight control and lifespan. In the cell, however, such functions are usually regulated by a sophisticated network of synergistic activities involving multiple components.
Fibroblast growth factor is involved in one such dual activity with extracellular matrix protein fibronectin.
The process of osteogenesis, for instance, is regulated by fibroblast growth factor which increases expression of fibronectin as it is secreted by differentiating osteoblasts (Tang et al., J Cell Physiol. 2007, 211(1):45-55).
A remarkable recent study showed that metallic implants coated with both fibronectin and fibroblast growth factor showed significantly increased bone-implant contact when compared to uncoated implants (Park et al., Intl J Oral Maxillo Implants, 2006, 21(6):859-866).
The synergistic effect of fibronectin and fibroblast growth factor has since been reported to be a critical feature of a number of cellular functions such as neuronal adhesion. To support this line of research, Akron offers a one stop shop destination for all your cellular and tissue engineering research needs. Akron’s line of fibroblast growth factors not only counts over a dozen different products, but our highly pure human plasma fibronectin allows the investigation of complex cellular behaviors that require specialized FGF activity beyond itself.
Contact us for more information.