FGF-21: Making you live longer?

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The fibroblast growth factor family counts 22 characterized members. While functions of most of those have been identified, elucidation of the exact mechanism and mode of action of some are still the subject of debate.  Lately, fibroblast growth factor-21 (FGF-21), has been the subject of increasing scientific interest, as its implications in weight control and lifespan are being discovered.

FGF-21, a potent activator of glucose uptake, is implicated in insulin resistance, metabolic syndrome, nonalcoholic fatty liver disease and weight control (Reinehr et al. JCEM; 2012, 97 (6): 2143) by functioning as a hormone to regulate carbohydrate and lipid metabolism. In recent studies, FGF-21 has been dubbed the “starvation hormone” (Dutchak et al.; Cell; 2012, 148(3):556–567) Results have shown that in mice, FGF-21 becomes induced in liver in response to prolonged fasts through a peroxisome proliferator-activated receptor α-dependent mechanism, which in turn causes adaptive starvation response (Zhang et al.; eLife 2012; 1:e00065). The study found that pharmacologic administration increased lifespan in test subjects, a remarkable find. This happens, it was discovered, by blunting the insulin-like growth factor-1 signaling pathway in the liver.

To support FGF research, Akron is a leading supplier of FGF-21. But it doesn’t stop there. Akron’s family of growth factors includes a vast array of FGFs, including human recombinant FGF-21, FGF-2 and FGF-9, which are available in research grade. FGF-21 is also available in cGMP compliant form with all documentation needed to support your regulatory filing. Contact us for more information.

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