Fibronectin and Vitronectin: Potent Siblings Responsible for Cell Migration and Tissue Repair

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Vitronectin sits alongside fibronectin as a key glycoprotein of the extracellular matrix and we are excited to announce its addition to the Akron Biotech family of cell adhesion proteins.

Just like its sibling, vitronectin is involved in cell attachment, migration, and differentiation. In the blood, vitronectin circulates in a monomeric form. Its interaction of with thrombin complexes or plasminogen activator inhibitor, results in its multimerization, which is its active form. Both fibronectin and vitronectin have been the subject of numerous research studies which reported on their remarkable role in tissue repair and wound healing. In one particular study on the recruitment of mesenchymal stem cells (MSCs) to damaged tissue sites, vitronectin and fibronectin have both been identified as being responsible for significant motogenic activity for MSCs at those sites (Thibault et al., Stem Cells and Development 2007). Because early stages of tumor progression induce the remodeling of the extracellular matrix which includes changes in levels of both fibronectin and vitronectin, this has a tremendous impact on tissue engineering as it allows the control of cell movement to and from patient-implanted, engineered cellular scaffolds through ECM activity.

The exact mechanisms by which cells interact with fibronectin and vitronectin in the extracellular matrix have also been the subject of a number of studies, and this line of research dates back over three decades (Rouslahti et al. Cancer Metastasis Rev 1984; Yamada et al. Cold Spring Harbor Symposia 1992). The synergy between extracellular matrix accumulation, vitronectin and fibronectin distribution and cell response presents remarkable coordination.

Akron Biotech now offers cGMP, research and high grade vitronectin and fibronectin for your research needs. Contact us today to discuss.

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